Reference documents
International Policies
Designing integrated care systems (ICSs) in England. A guide from NHS (National Heath Services), setting out the levels of management that make up an integrated care system, describing their core functions, the rationale behind them and how they will work together.
Martin LA, Mate K. IHI Innovation System. IHI White Paper. Boston, Massachusetts: Institute for Healthcare Improvement; 2018. The Institute for Healthcare Improvement (IHI) is a leading innovator in health and health care improvement worldwide
ICT strategies
ICT Strategy in The Catalan HealthCare and Social Care System Fundació TIC Salut and Generalitat de Catalunya
Solans Fernández Ò. et al. (2017) Shared Medical Record, Personal Health Folder and Health and Social Integrated Care in Catalonia: ICT Services for Integrated Care . In: Rinaldi G. (eds) New Perspectives in Medical Records. TELe-Health. Springer, Cham
Catalan Health Care system
The Catalan Health Care System in a Process of Change. Review of the 2011-2015 Health Plan for Catalonia at the Halfway Point
From the Catalan model of health to the Catalan healthcare system, Generalitat de Catalunya, Departament e Salut
Integrated care
Font et al. Integrated Health Care Barcelona Esquerra (Ais-Be): A Global View of Organisational Development, Re-Engineering of Processes and Improvement of the Information Systems.. Int J Integr Care. 2016 May 23;16(2):8. doi: 10.5334/ijic.2476.
Contel JC at al. Chronic and integrated care in Catalonia . Int J Integr Care. 2015 Jun 29;15:e025. eCollection 2015 Apr-Jun.
Team's papers
InCaSyM 2019' papers
Baltaxe E, Cano I, Herranz C, Barberan-Garcia A, Hernandez C, Alonso A, Arguis MJ, Bescos C, Burgos F, Cleries M, Contel JC, de Batlle J, Islam K, Kaye R, Lahr M, Martinez-Palli G, Miralles F, Moharra M, Monterde D, Piera J, Ríos J, Rodriguez N, Ron R, Rutten-van Mölken M, Salas T, Santaeugenia S, Schonenberg H, Solans O, Torres G, Vargiu E, Vela E and Roca J, Evaluation of integrated care services in Catalonia: population-based and service-based real-life deployment protocols , BMC Health Services Research 201919:370 https://doi.org/10.1186/s12913-019-4174-2©
Roca J, Tenyi A and Cano I. Paradigm changes for diagnosis: using big data for prediction , Clin Chem Lab Med 2019; Vol 57, Issue 3, pp 317-327: https://doi.org/10.1515/cclm-2018-0971
* Opinion paper, Lecture given by Prof. Josep Roca at 2nd EFLM Strategic Conference, 18–19 June 2018 in Mannheim (Germany).
Barberan-Garcia A, Munoz PA, Gimeno-Santos E, Burgos F, Torralba Y, Gistau C, Roca J, Rodriguez DA, Training-induced changes on quadriceps muscle oxygenation measured by nirs in healthy subjects and in COPD Patients , Clin Physiol Funct Imaging. 2019 Apr 23. doi: 10.1111/cpf.12572
InCaSyM 2018' papers
Vela E, Tényi Á, Cano I et al. Population-based analysis of patients with COPD in Catalonia: a cohort study with implications for clinical management. BMJ Open. March; 6;8(3):e017283, DOI: 10.1136/bmjopen-2017-017283
Cano I, Tenyi A, Vela E, Miralles F, Roca J. Perspectives on Big Data applications of health information. Curr Opin Syst Biol 2017;3:36–42.
Tényi Á, Vela E, Cano I, Cleries M, Monterde D, Gomez-Cabrero D, Roca J. Risk and temporal order of disease diagnosis of comorbidities in patients with COPD: a population health perspective. BMJ Open Respir Res. 2018 Jun 13;5(1):e000302.
Tényi Á, Cano I, Marabita F, Kiani N, Kalko SG, Barreiro E, de Atauri P, Cascante M, Gomez-Cabrero D, Roca J. Network modules uncover mechanisms of skeletal muscle dysfunction in COPD patients. J Transl Med. 2018 Feb 20;16(1):34.
InCaSyM 2017' papers
Marín de Mas I, Fanchon E, Papp B, Kalko S, Roca J, Cascante M. Molecular mechanisms underlying COPD-muscle dysfunction unveiled through a systems medicine approach. Bioinformatics, Volume 33, Issue 1, 1st January, 95–103, DOI: 10.1093/bioinformatics/btw566
InCaSyM 2016' papers
Tényi, Á.; de Atauri, P.; Gomez-Cabrero, D et al. ChainRank, a chain prioritisation method for contextualisation of biological networks. BMC Bioinformatics. 2016; 9 (17):1-17.
Dueñas-Espín I; Vela E; Pauws S et al. Proposals for enhanced health risk assessment and stratification in an integrated care scenario. BMJ Open. 2016; 6:e010301
Roca J, Cano I, Gomez-Cabrero D, Tegnér J. From Systems Understanding to Personalized Medicine: Lessons and Recommendations Based on a Multidisciplinary and Translational Analysis of COPD. Methods Mol Biol. 2016;1386:283-303. doi:10.1007/978-1-4939-3283-2_13
Roca, J., 2016. From comorbidities of COPD to identification of shared molecular mechanisms by data integration. BMC Bioinformatics. Nov 22;17(Suppl 15):441. doi: 10.1186/s12859-016-1291-3.
InCaSyM 2015' papers
Cano I, Roca J, Wagner PD. Effects of lung ventilation-perfusion and muscle metabolism-perfusion heterogeneities on maximal O2 transport and utilization. J Physiol. 2015 Apr 15;593(8):1841-56.
Puig-Vilanova E, Martínez-Llorens J, Ausin P, Roca J, Gea J, Barreiro E. Quadriceps muscle weakness and atrophy are associated with a differential epigenetic profile in advanced COPD. Clin Sci (Lond). 2015;128(12):905-2, DOI: 10.1042/CS20140428
Puig-Vilanova E, Rodriguez DA, Lloreta J, Ausin P, Pascual-Guardia S, Broquetas J, Roca J, Gea J, Barreiro E. Oxidative stress, redox signaling pathways, and autophagy in cachectic muscles of male patients with advanced COPD and lung cancer. Free Radic Biol Med. 2015; 79:91-108.
Agustí, A.; Antó, J.M.; Auffray, C et al. Personalized Respiratory Medicine: Exploring the Horizon, Addressing the Issue s. Ame Journal of Respir and Crit Care Med. 2015;
InCaSyM 2014' papers
Cano I, Lluch-Ariet M, Gomez-Cabrero D, Maier D, Kalko S, Cascante M, Tegnér J, Miralles F, Herrera D, Roca J; Synergy-COPD consortium. Biomedical research in a Digital Health Framework. J Transl Med. 2014 Nov 28;12 Suppl 2:S10. doi: 10.1186/1479-5876-12-S2-S10
Cano I, Tényi Á, Schueller C, Wolff M, Huertas Migueláñez MM, Gomez-Cabrero D, Antczak P, Roca J, Cascante M, Falciani F, Maier D. The COPD Knowledge Base: enabling data analysis and computational simulation in translational COPD research. J Transl Med. 2014 Nov 28;12 Suppl 2:S6. doi:10.1186/1479-5876-12-S2-S6
Gomez-Cabrero D, Lluch-Ariet M, Tegner J, Cascante M, Miralles F, Roca J, consortium tS-C: Synergy-COPD: a systems approach for understanding and managing chronic diseases. Journal of Translational Medicine 2014, 12:S2..
Roca J, Vargas C, Cano I, Selivanov V, Barreiro E, Maier D, Falciani F, Wagner P, Cascante M, Garcia-Aymerich J, et al: Chronic Obstructive Pulmonary Disease heterogeneity: challenges for health risk assessment, stratification and management. Journal of Translational Medicine 2014, 12:S3.
Gomez-Cabrero D, Menche J, Cano I, Abugessaisa I, Huertas-Miguelanez M, Tenyi A, de Mas I, Kiani N, Marabita F, Falciani F, et al: Systems Medicine: from molecular features and models to the clinic in COPD. Journal of Translational Medicine 2014, 12:S4.
Burrowes K, Doel T, Brightling C: Computational modeling of the obstructive lung diseases asthma and COPD. Journal of Translational Medicine 2014, 12:S5.
Miguelanez MMH, Mora D, Cano I, Maier D, Gomez-Cabrero D, Lluch-Ariet M, Miralles F: Simulation environment and graphical visualization environment: a COPD use-case. Journal of Translational Medicine 2014, 12:S7.
Lluch-Ariet M, de la Torre A, Vallverdu F, Pegueroles-Valles J: Knowledge sharing in the health scenario. Journal of Translational Medicine 2014, 12:S8.
Velickovski F, Ceccaroni L, Roca J, Burgos F, Galdiz JB, Marina N, Lluch-Ariet M: Clinical Decision Support Systems (CDSS) for preventive management of COPD patients. Journal of Translational Medicine 2014, 12:S9.
Cascante M, Pedro de Atauri, David Gomez-Cabreo, Peter Wagner et al. Workforce preparation: the Biohealth computing model for Master and PhD students. Journal of Translational Medicine 2014, 12:S11.
Miralles F, Gomez-Cabrero D, Lluch-Ariet M, Tegner J, Cascante M, Roca J, consortium S-C: Predictive medicine: outcomes, challenges and opportunities in the Synergy-COPD project. Journal of Translational Medicine 2014, 12:S12.
Maltais, F.; Decramer, M.; Casaburi et al. An Official American Thoracic Society/European Respiratory Society Statement: Update on Limb Muscle Dysfunction in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2014; 1;189(9):e15-62.
Grosdidier, S.; Ferrer, A.; Faner, R.; Piñero J,; Roca, J.; Cosío, B.; Agustí, A.; Gea, J.; Sanz F.; Furlong, L. Network medicine analysis of COPD multimorbidities. Respiratory Research. 2014;
Davidsen, PK.; Herbert, JM.; Antczak, P et al.: A systems biology approach reveals a link between systemic cytokines and skeletal muscle energy metabolism in a rodent smoking model and human COPD. Genome Medicine.2014; 6: 59-66
Cano, I.; Selivanov, V.; Gomez-Cabrero, D.; Tegnér, J.; Roca, J.; Wagner, P.D.; Cascante, M. Oxygen pathway modeling estimates high Reactive oxygen species production above the highest permanent human habitation. PLoS One. 2014; 9: e111068